Background: Polycystic Ovarian Disease (PCOD) represents the most prevalent endocrine disorder in reproductive-aged women (5-26% prevalence). Unani medicine conceptualizes PCOD as Sue-Mizaj (dystemperament) disorder with balgham (phlegm) predominance, offering evidence-based integrative management.
Methods: Systematic review of classical Unani texts (Ibn Sina’s Al-Qanun fi’l-Tibb, Al-Razi’s Kitab al-Hawi, Al-Zahrawi’s Al-Tasrif) integrated with contemporary clinical trials and mechanistic pharmacology studies. Analysis of 40+ peer-reviewed publications examining polyherbal formulations, lifestyle modifications based on Asbab-e-Sitta-Zarooriah principles, and regimental therapies.
Results: Clinical trials demonstrate Unani formulations achieve LH/FSH ratio reduction (44%, p<0.0001), menstrual cycle regularization (61-84% improvement), prolactin reduction (40-50%), and fertility improvement comparable or superior to metformin with enhanced safety profiles. Integrative approach combining pharmacotherapy, diet therapy (Ilaj Bil Ghiza), and regimental therapy (Ilaj Bil Tadbeer) produces synergistic outcomes superior to any single intervention.
Conclusion: Unani medicine’s Sue-Mizaj conceptualization aligns with modern pathophysiology. Evidence-based polyherbal formulations utilizing emmenagogue, insulin-sensitizing, and phlegm-transforming herbs offer cost-effective, safe management addressing root constitutional imbalance rather than symptom suppression alone.
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