2024, Vol. 6, Issue 5, Part A

Author(s): Maria Gutierrez and Stefan Müller

Abstract: Polyphenols, a diverse group of bioactive compounds found abundantly in fruits, vegetables, and beverages like tea and wine, have attracted considerable attention for their potential health benefits. One of the key mechanisms through which polyphenols exert their effects is the inhibition of the mechanistic target of rapamycin (mTOR) pathway, which plays a pivotal role in regulating cellular growth, metabolism, and inflammation. The mTOR pathway, when dysregulated, is implicated in various chronic inflammatory diseases such as rheumatoid arthritis, atherosclerosis, and neurodegenerative disorders. Polyphenolic compounds, including flavonoids, resveratrol, and curcumin, have demonstrated the ability to modulate mTOR signaling, potentially offering therapeutic strategies for managing these diseases. This systematic review explores the role of polyphenols as natural inhibitors of the mTOR pathway and their implications for the management of chronic inflammatory diseases. We delve into the molecular mechanisms by which polyphenols interact with mTOR signaling, highlighting key studies that illustrate their anti-inflammatory and disease-modulating properties. Furthermore, we examine the potential of polyphenols in combination therapies, alongside their safety profiles and bioavailability concerns. While promising, the clinical translation of polyphenol-based therapies requires further investigation into optimal dosing, delivery methods, and long-term efficacy. The findings underscore the need for continued research to fully establish polyphenols as viable adjunctive treatments in the management of chronic inflammatory diseases, with the ultimate goal of improving patient outcomes and quality of life.

DOI: 10.22271/multi.2024.v6.i5a.878

Pages: 159-163 | Views: 101 | Downloads: 51

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